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Vitamin B12 (Cyanocobalamin) Injection USP 1000 mcg/mL, 10mL Bottle (Prescription Product)

$125.00
SKU
VB12-0001-20-MRX-01

Safeguard your health with affordable at-home B12 intramuscular or subcutaneous injections. Your body needs Vitamin B12 but are you getting enough of it? B12 plays a role in close to 100 different body functions 1. It's required for DNA synthesis, protein and amino acid metabolism, and helps prevent birth defects 2,  but your body can't make it.  Each bottle lasts up to 70 days. Suitable for vegans. 1000 mcg/ml. 10 ml bottle. We must obtain a prescription from your provider before we can fill your order.

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B12 injections deliver the fastest benefits of the essential vitamin

Pharmaceutical-grade, prescription-only Vitamin B12 shots from Mint Pharmacy are vegan and contain cyanocobalamin, a form of B12 that is readily converted for use by the body. Find out how you can give yourself B12 injections right at home to boost your B12 levels and maintain them. 

One of the most obvious perks of Vitamin B12 shots is increased energy. Many people report feeling a burst of energy within a day of receiving a B12 injection. Although high energy is great and B12 is popular in preventative medicine, B12 shots can benefit the body in more vital ways.

Close to 100 body processes involve B12. Among them: B12 protects the health of neurons and red blood cells, is needed to produce energy, protects the Central Nervous System (CNS) and supports immunity.

How long do B12 shots last?

Most people report that the effects of 1000 mcg of B12 last for about a week and typical dosing is 1x week.

Why B12 shots are effective

There are more than a few obstacles to Vitamin B12 absorption by the body from food and oral supplements. Oral supplements include tablets, capsules, sublingual drops and lozenges. The only way these delivery methods can be used by the body is through absorption in the small intestine. In a best case scenario, the body can absorb 2% of oral Vitamin B12 supplements in a 12-hour period.3 It is not known how much B12 from food is available for use by the body but the fact that 15% of the US population4 is Vitamin B12 deficient provides insight. Like many vitamins, how and when the B12 is taken orally affects its absorption.

What causes B12 deficiency?

Causes of B12 deficiency include Crohn’s and Celiac disease, prescription and over the counter medications to treat acid reflux and Gastroesophageal Reflux Disease (GERD), prescriptions such as Metformin, medical procedures like bariatric surgery and low levels of the glycoprotein intrinsic factor.5 It's also common for some people to poorly absorb vitamins for unknown reasons.6

A popular misconception about B12 deficiency is that vegans, vegetarians and the elderly are the only groups at risk for B12 deficiency. It's true that elderly adults are more prone to B12 deficiency due to a decline in absorption associated with aging.7

It's also true that sufficient amounts of dietary B12 only comes from animal products. No plants make Vitamin B12 in any significant amount, except perhaps the smallest plant known on earth, duckweed (Wolffia globosa.) Duckweed is being studied due to its nutrient-rich profile which includes Vitamin B12, nine of the essential amino acids, iron, and zinc.

Overall, studies show that Vitamin B12 deficiency is not limited to age or diet.

How B12 shots work

B12 shots are given intramuscularly or subcutaneously which bypasses the digestive system. Parenteral administration (injection) is faster and more efficient than oral supplements and recommended for initial or continued treatment of B12 deficiency depending on the cause and the individual with the deficiency.9

It is well documented that there is no risk of Vitamin B12 overdose.10 The body uses as much as it needs and excretes the excess through urine.

What are signs of low B12?

  • Fatigue and reduced strength
  • Dizziness
  • Shortness of breath
  • Nausea 
  • Loss of appetite
  • Weight loss
  • Diarrhea or constipation

References

1 Vitamin B12 Fact Sheet for Health Professionals.
https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/#en27. Accessed September 4, 2019

Dunham, Will. Vitamin B12 can prevent major birth defects. Reuters. March 2, 2019. https://www.reuters.com/article/us-birth-defects/vitamin-b12-can-prevent-major-birth-defects-idUSTRE5210MT20090302. Accessed: September 4, 2019.

3-7 Vitamin B12 Fact Sheet for Health Professionals.
https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/#en27. Accessed September 4, 2019

Kaplan, Alon et al. Protein bioavailability of Wolffia globosa duckweed, a novel aquatic plant, - A randomized controlled trial. December 11, 2018. Clin Nutr. 2018 Dec 11. doi: 10.1016/j.clnu.2018.12.009. https://www.ncbi.nlm.nih.gov/pubmed/30591380

9 Vitamin B12 Deficiency.  https://www.health.harvard.edu/a_to_z/vitamin-b12-deficiency-a-to-z Harvard Health Publishing. Published: March 2019. Accessed: September 3, 2019.

10 Vitamin B12 Fact Sheet for Health Professionals.
https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/#en27. Accessed September 4, 2019

More Information
Use or Effects Vitamin B12 Deficiency, Vitamin Supplement
Is a Prescription Product N/A
Drug Class/Pharmacology Vitamins
Form Aqueous Solution for Injection
Product Specifics

CONTRAINDICATIONS

Sensitivity to cobalt and/or vitamin B12 is a contraindication.

WARNINGS

Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy.

Hypokalemia and sudden death may occur in severe megaloblastic anemia which is treated intensely.

Anaphylactic shock and death have bee

This product contains Benzyl Alcohol. Benzyl Alcohol has been reported to be associated with a fatal "Gasping Syndrome" in premature infants.

This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired.

Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

PRECAUTIONS

General

Vitamin B12 deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord. Doses of folic acid greater than 0.1 mg per day may result in hematologic remission in patients with vitamin B12 deficiency. Neurologic manifestations will not be prevented with folic acid, and if not treated with vitamin B12, irreversible damage will result.

Doses of cyanocobalamin exceeding 10 mcg daily may produce hematologic response in patients with folate deficiency. Indiscriminate administration may mask the true diagnosis.

Information for Patients

Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives. Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord. Also, patients should be warned about the danger of taking folic acid in place of vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration.

A vegetarian diet which contains no animal products (including milk products or eggs) does not supply any vitamin B12. Patients following such a diet, should be advised to take oral vitamin B12 regularly. The need for vitamin B12 is increased by pregnancy and lactation. Deficiency has been recognized in infants of vegetarian mothers who were breast fed, even though the mothers had no symptoms of deficiency at the time.

Laboratory Tests

During the initial treatment of patients with pernicious anemia, serum potassium must be observed closely the first 48 hours and potassium replaced if necessary.

Hematocrit, reticulocyte count, vitamin B12, folate and iron levels should be obtained prior to treatment. Hematocrit and reticulocyte counts should be repeated daily from the fifth to seventh days of therapy and then frequently until the hematocrit is normal. If folate levels are low, folic acid should also be administered. If reticulocytes have not increased after treatment or if reticulocyte counts do not continue at least twice normal as long as the hematocrit is less than 35%, diagnosis or treatment should be reevaluated. Repeat determinations of iron and folic acid may reveal a complicating illness that might inhibit the response of the marrow.

Patients with pernicious anemia have about 3 times the incidence of carcinoma of the stomach as the general population, so appropriate tests for this condition should be carried out when indicated.

Drug/Laboratory Test Interactions

Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays.

Colchicine para-aminosalicylic acid and heavy alcohol intake for longer than 2 weeks may produce malabsorption of vitamin B12.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long term studies in animals to evaluate carcinogenic potential have not been done. There is no evidence from long-term use in patients with pernicious anemia that cyanocobalamin is carcinogenic. Pernicious anemia is associated with an increased incidence of carcinoma of the stomach, but this is believed to be related to the underlying pathology and not to treatment with cyanocobalamin.

Pregnancy

Teratogenic Effects: Pregnancy Category C

Adequate and well-controlled studies have not been done in pregnant women. However, vitamin B12 is an essential vitamin and requirements are increased during pregnancy. Amounts of vitamin B12  that are recommended by the Food and Nutrition Board, National Academy of Science-National Research Council for pregnant women (4 mcg daily) should be consumed during pregnancy.

Nursing Mothers

Vitamin B12 is known to be excreted in human milk. Amounts of vitamin B12 that are recommended by the Food and Nutrition Board, National Academy of Science-National Research Council for lactating women (4 mcg daily) should be consumed during lactation.

Pediatric Use

Intake in children should be in the amount (0.5 to 3 mcg daily) recommended by the Food and Nutrition Board, National Academy of Science-National Research Council.

ADVERSE REACTIONS

Generalized

Anaphylactic shock and death have been reported with administration of parenteral vitamin B12 (see WARNINGS).

Cardiovascular

Pulmonary edema and congestive heart failure early in treatment; peripheral vascular thrombosis. 

Hematological

Polycythemia vera

Gastrointestinal

Mild transient diarrhea

Dermatological

Itching; transitory exanthema

Miscellaneous

Feeling of swelling of entire body

What is Cyanocobalamin?

Cyanocobalamin is the manufactured version of the B12 Vitamin. All supplemental B12 is manufactured. The body cannot make Vitamin B12. B12 is available naturally to the body by consuming animal products. Only a few plants are known to make B12 and the amount is insufficient to impact B12 levels in humans.

How much B12 is in each injection?

Each 1 ml injection contains 1000 mcg B12 as Cyanocobalamin. Many patients start with 1 ml a week, but your physician will make the final determination.

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