Toggle Nav
My Cart

Compounded Estradiol - DHEA Vaginal Cream


Estradiol with dehydroepiandrosterone (DHEA) is prescribed to treat symptoms of menopause including vaginal dryness, pain during sex, thinning of vaginal walls, low libido, mood swings, and hot flashes. These unpleasant symptoms commonly result from the natural decline in sex hormone production by the body during the aging process. Estradiol and DHEA replacement has been shown to help relieve vaginal symptoms. Additonally DHEA can replace testosterone. Balancing testosterone may stabilize mood and help reduce hot flashes. The strength of active ingredients in this custom-compounded formula are estradiol 0.0125% and 1% DHEA/ gram. The 45gm tube comes with 3 applicators.

Save 5% with Auto-Refill! Cancel anytime.

Simply use coupon code SAVE in checkout cart.

Boost estrogen and testosterone with estrogen plus DHEA vaginal cream

Estrogen, testosterone and DHEA naturally decline as women age, reaching their lowest levels after menopause. Estradiol is the strongest of the body's three estrogens and the main female sex hormone. Estrogen is mainly responsible for female secondary sex characteristics. DHEA is an androgen sex hormone made by the adrenal glands. It transforms into estrogen or testosterone. 

The estrogen and DHEA used in this formula are defined as bio-identical. They are plant-based and produced from diosgenin, an extract of the wild yam. The diosgenin must undergo a 3-step chemical process done in a lab to produce the estrogen. Studies show that eating the wild yam is not effective for ERT or any HRT.

How can DHEA help me?

DHEA is especially important because it is responsible for the creation of all estrogen in women. 

Studies show DHEA hormone replacement therapy in women is effective in helping support regrowth of epithelial cells that make up the vaginal lining. Vaginal delivery of DHEA may also offer special benefits for women who need or want to keep their systemic estrogen levels down.1 However, only a physician can make the recommendation. 

Clinical trials with DHEA hormone replacement therapy in women have shown DHEA increases protein Insulin Growth Factor (IGF-1) and helps metabolize fat in women.2

The belief is that direct DHEA absorption into the vagina is transformed into estradiol without raising the body's systemic estrogen.3

  • DHEA treatment can reduce pain during sex by rejuvenating the vaginal walls. 4
  • Topically applied DHEA has been shown to help boost skin cell growth in women over 60.5
  • Studies show DHEA replacement can elevate women's moods to relieve depression.6

Testosterone is essential to women. It supports growth, repair of reproductive tissues and drives female libido. Low testosterone in women can also cause low energy, low libido and interfere with the ability to concentrate.7 Boosting testosterone indirectly with DHEA may help improve those symptoms. 

What is compounded medicine?

Compounded medications are made by experts who develop recipes specifically for each patient based on their medical condition and needs. They are prepared in small batches and do not require commercial fillers and preservatives that industrial pharmaceuticals require for a long shelf life.

Another bonus: Custom-compounded medications may cost up to 50% to 75% less than commercial prescriptions.

Mint Pharmacy's expert compounding pharmacists create customized prescriptions from scratch using the same active ingredients found in commercially available prescriptions and obtains medications from FDA-approved sources. 

Why should I buy compounded medicine from Mint Pharmacy?

With the benefit of personalized medicine at affordable prices, Mint Pharmacy's solutions provide relief for your mind as well as your body. Private, free shipping with the convenience of auto refills and online medical consultations help you continue your HRT.

Mint Pharmacy is a US certified pharmacy and is accredited by the Pharmacy Compounding Accreditation Board (PCAB).

This product is custom-made by expert compounding pharmacists. These statements have not been evaluated by the Food and Drug Administration (FDA). Please consult your physician before starting any exercise or nutritional supplement program before using this or any products if you are pregnant or have a serious medical condition.


1Seaman, Andrew. DHEA vaginal suppository good alternative to estrogen creams. Health News. Reuters. Jan. 5, 2016. Online: Last visited Oct. 10, 2019.

DHEA Makes the fat go away. Harvard Health Publishing. March 2014. Online:

3,4 Seaman, Andrew. DHEA vaginal suppository good alternative to estrogen creams. Health News. Reuters. Jan. 5, 2016. Online: Last visited Oct. 10, 2019.

5,6 DHEA: MedLinePlus, U.S. National Library of Medicine, U.S. Department of Health and Human Services National Institutes of Health. Online: Last visited Oct. 10. 2019.

Testosterone for Women. Women's Health Concern, British Menopause Society. Online: Last visited Oct. 10, 2019.

More Information
Use or Effects Menopause Symptoms, Relieve Pain During Sex, Treat Vaginal Dryness, Hormone Replacement Therapy
Is a Prescription Product Yes
Form Cream
Drug Class/Pharmacology Estrogens, Androgens
Product Specifics

This custom compounded cream contains estradiol and DHEA 0.0125 estradiol and 1% DHEA per gram in a cream.

This prescription-only product is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause. Symptoms of 

Estradiol vaginal cream and DHEA should not be used in women with any of the following conditions:

  • Undiagnosed abnormal genital bleeding.
  • Known, suspected, or history of cancer of the breast.
  • Known or suspected estrogen-dependent neoplasia.
  • Active DVT, PE or history of these conditions.
  • Active arterial thromboembolic disease (for example, stroke, MI) or a history of these conditions.
  • Known anaphylactic reaction or angioedema to estradiol vaginal cream 0.01%.
  • Known liver dysfunction or disease.
  • Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders.
  • Known or suspected pregnancy

What does estrogen do?

Estrogen's primary role in women is to regulate the reproductive system. It's also responsible for female secondary sexual characteristics that differentiate females from males.

What causes low estrogen?

Estrogen naturally decreases in women as she approaches menopause. Before menopause, estrogen ranges from 15 to 350 picograms per milliliter (pg/mL). In post-menopausal women, estrogen falls below 30 pg/mL. Estrogen can also decline in women of any age. Childbirth, stress and illness and age are also among the causes. 

What are symptoms of menopause and low estrogen?

  • Poor sleep
  • Insomnia
  • Anxiety
  • Weight gain
  • Frequent mood changes
  • Depression
  • Vaginal dryness
  • Pain during sex caused by vaginal dryness
  • Decreased libido
  • Hot flashes

Decreased estrogen puts postmenopausal women at high risk for osteoporosis. Out of the 10 million people in the US who have osteoporosis, 80% are women.1

Additionally, low estrogen it is linked to thinning of vaginal tissue and vaginal dryness, both of which are main causes of vaginal atrophy and pain during sex.

What is estrogen replacement therapy (ERT) used for?

  • Relief of menopause symptoms
  • Treating low libido associated with low estrogen
  • Relieving vaginal dryness and pain during sex
  • Preventing osteoporosis
  • Treating ovarian failure
  • Feminizing hormone therapy
  • Maintaining the health of the vagina
  • Treating hormonal imbalance

What are the benefits of taking DHEA in women?

Hormone replacement therapy in women with low DHEA due to age, surgical removal of the ovaries or early menopause has been shown to produce several benefits in women:

  • Increase estradiol levels 2
  • Increase libido by helping restore testosterone levels 3
  • Slow aging 4
  • Slow cognitive decline 5
  • Increase testosterone levels


What Women Need to Know. National Osteoporosis Foundation. Online: Last visited: Oct. 11, 2019.

2, 3,4,5 Zhou Y, Kang J, Chen D, Han N, Ma H. Ample Evidence: Dehydroepiandrosterone (DHEA) Conversion into Activated Steroid Hormones Occurs in Adrenal and Ovary in Female Rat. PLoS One. 2015;10(5):e0124511. Published 2015 May 11. doi:10.1371/journal.pone.0124511

Write Your Own Review
You're reviewing:Compounded Estradiol - DHEA Vaginal Cream
Your Rating