Estradiol/DHEA Vaginal Cream

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FSA and HSA Eligible

How it works

Step 1. No Prescription?

No problem! Choose "I need a prescription" and get treated online by one of our participating providers in just 5 minutes. Avoid the hassle and expense of visiting a doctor's office.

Step 2. You Have a Prescription

Simply upload a photo of your prescription after checkout. You can also text us a picture of your prescription or prescription label to 561-406-9485. We will fax/efax your doctor to confirm the prescription or your physician can "EScript" (send electronically) your prescription to our pharmacy at Mint Pharmacy and Skin Clinic, 1201 US Hwy 1 Ste 305C, North Palm Beach Florida.
Only choose "I have a prescription" if your doctor can validate and has prescribed this specific drug and dosage.

Step 3. Your Order Is Processed

Once your prescription is received, we will process your order. We only pre-authorize your credit card at checkout and you won't see a charge on your card until we obtain a valid prescription.

Step 4. Your Medication Is Shipped

Never wait in a pharmacy line again! Your medication is on its way, directly to your door.

Estradiol with Dehydroepiandrosterone (DHEA) is prescribed to treat symptoms of menopause including vaginal dryness, pain during sex, thinning of vaginal walls, low libido, mood swings, and hot flashes. DHEA may also balance testosterone. Studies show testosterone replacement helps stabilize mood and reduce hot flashes. The strength of active ingredients in this custom-compounded formula are estradiol 0.0125% and 1% DHEA/gram. Includes 1 applicator. 30 grams per tube.

Please note: We cannot provide telemedicine for this product in LA or SC. We cannot offer this medication in Iowa

Prescription Product: We will ask for your prescription information after checkout.

Estrogen-DHEA To Boost Estrogen & Testosterone

Estrogen, testosterone and DHEA naturally decline as women age, reaching their lowest levels after menopause. Estradiol is the strongest of the body's three estrogens and the main female sex hormone. Estrogen is mainly responsible for female secondary sex characteristics. DHEA is an androgen sex hormone made by the adrenal glands. It transforms into estrogen or testosterone. DHEA is especially important because it is responsible for the creation of all estrogen in women. 

How Can HRT With DHEA Help Me?

Studies show DHEA Bioidentical Hormone Replacement therapy (BRT) in women is effective in helping support regrowth of epithelial cells that make up the vaginal lining. Vaginal delivery of DHEA may also offer special benefits for women who need or want to keep their systemic estrogen levels down.1 However, only a physician can make the recommendation. 

Clinical trials with DHEA hormone replacement therapy in women have shown DHEA increases protein Insulin Growth Factor (IGF-1) and helps metabolize fat in women.2

The belief is that direct DHEA absorption into the vagina is transformed into estradiol without raising the body's systemic estrogen.3

  • DHEA treatment can reduce pain during sex by rejuvenating the vaginal walls. 4
  • Topically applied DHEA has been shown to help boost skin cell growth in women over 60.5
  • Studies show DHEA replacement can elevate women's moods to relieve depression.6

Testosterone is essential to women. It supports growth, repair of reproductive tissues and drives female libido. Low testosterone in women can also cause low energy, low libido and interfere with the ability to concentrate.7 Boosting testosterone indirectly with DHEA may help improve those symptoms. 

Bioidentical Hormones vs Phytohormones

There is a lot of "talk" about phytohormones for HRT. Phytohormones are plant-based compounds that are similar to endogenous hormones produced by the body. One of the most well-known phytohormones is phytoestrogen. Well-known sources for phytoestrogens are soy and kava kava.

Bioidentical hormones are also plant-based, but offer a significant advantage. 

Phytohormones are sold as supplements and do not require a prescription. Using these products without expert medical guidance may, and in some cases, has caused more harm than good. Without monitoring of hormone levels, you run the risk of exacerbating hormonal imbalance.

Advantages of BRT:

  • Bioidentical hormones are exact replicas of the body's endogenous hormones.
  • The body does not distinguish bioidentical hormones from its own and processes them the same.
  • Bioidentical hormones are plant-based.
  • US FDA law requires that bioidentical hormones must all come from one specific plant.
  • Bioidentical hormones require a prescription which provides the added benefit of ongoing medical care. Make sure your physician has expertise in BRT and offers continuous lab testing.
  • HRT goals are more easily controlled with bioidentical hormones.

Whether you chose to use phytoestrogens or not for HRT, is your choice, but it is important to make an educated decision.

Where Do Bioidentical Hormones Come From?

They are created from diosgenin, a chemical extracted from with wild yam or soy. The diosgenin must undergo a 3-step chemical process done in a lab to produce the estrogen.

What Is Compounded Medicine?

Compounded medications are made by experts who develop recipes specifically for each patient based on their medical condition and needs. They are prepared in small batches and do not require commercial fillers and preservatives that industrial pharmaceuticals require for a long shelf life

Another bonus: Custom-compounded medications may cost up to 50% to 75% less than commercial prescriptions.

Mint Pharmacy's expert compounding pharmacists create customized prescriptions from scratch using the same active ingredients found in commercially available prescriptions and obtains medications from FDA-approved sources. 

Why Should I Buy From MintRx?

With the benefit of personalized medicine at affordable prices, MinRx's solutions provide relief for your mind as well as your body. Private, free shipping with the convenience of auto refills and online medical consultations help you continue your HRT.


1Seaman, Andrew. DHEA vaginal suppository good alternative to estrogen creams. Health News. Reuters. Jan. 5, 2016. Online: Last visited Oct. 10, 2019.

DHEA Makes the fat go away. Harvard Health Publishing. March 2014. Online:

3,4 Seaman, Andrew. DHEA vaginal suppository good alternative to estrogen creams. Health News. Reuters. Jan. 5, 2016. Online: Last visited Oct. 10, 2019.

5,6 DHEA: MedLinePlus, U.S. National Library of Medicine, U.S. Department of Health and Human Services National Institutes of Health. Online: Last visited Oct. 10. 2019.

Testosterone for Women. Women's Health Concern, British Menopause Society. Online: Last visited Oct. 10, 2019.

These products are made by a MintRx partner, a 3rd party licensed, sterile compounding pharmacy. These statements have not been evaluated by the Food and Drug Administration (FDA). Please consult your physician before starting any exercise or nutritional supplement program before using this or any products if you are pregnant or have a serious medical condition.

What Does Estrogen Do?

Estrogen's primary role in women is to regulate the reproductive system. It's also responsible for female secondary sexual characteristics that differentiate females from males.

What Causes Low Estrogen?

Estrogen naturally decreases in women as she approaches menopause. Before menopause, estrogen ranges from 15 to 350 picograms per milliliter (pg/mL). In post-menopausal women, estrogen falls below 30 pg/mL. Estrogen can also decline in women of any age. Childbirth, stress and illness and age are also among the causes. 

What Are Symptoms Of Menopause And Low Estrogen?

  • Poor sleep
  • Insomnia
  • Anxiety
  • Weight gain
  • Frequent mood changes
  • Depression
  • Vaginal dryness
  • Pain during sex caused by vaginal dryness
  • Decreased libido
  • Hot flashes

Decreased estrogen puts postmenopausal women at high risk for osteoporosis. Out of the 10 million people in the US who have osteoporosis, 80% are women.1

Additionally, low estrogen it is linked to thinning of vaginal tissue and vaginal dryness, both of which are main causes of vaginal atrophy and pain during sex.

What IS Estrogen Replacement Therapy (ERT) Used For?

  • Relief of menopause symptoms
  • Treating low libido associated with low estrogen
  • Relieving vaginal dryness and pain during sex
  • Preventing osteoporosis
  • Treating ovarian failure
  • Feminizing hormone therapy
  • Maintaining the health of the vagina
  • Treating hormonal imbalance

What Are The Benefits Of DHEA For Female HRT?

Hormone replacement therapy in women with low DHEA due to age, surgical removal of the ovaries or early menopause has been shown to produce several benefits in women:

  • Increase estradiol levels 2
  • Increase libido by helping restore testosterone levels 3
  • Slow aging 4
  • Slow cognitive decline 5
  • Increase testosterone levels


1What Women Need to Know. National Osteoporosis Foundation. Online: Last visited: Oct. 11, 2019.

2, 3,4,5 Zhou Y, Kang J, Chen D, Han N, Ma H. Ample Evidence: Dehydroepiandrosterone (DHEA) Conversion into Activated Steroid Hormones Occurs in Adrenal and Ovary in Female Rat. PLoS One. 2015;10(5):e0124511. Published 2015 May 11. doi:10.1371/journal.pone.0124511

This prescription-only product may treat moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.  

Estradiol vaginal cream and DHEA should not be used in women with any of the following conditions:

  • Undiagnosed abnormal genital bleeding.
  • Known, suspected, or history of cancer of the breast.
  • Known or suspected estrogen-dependent neoplasia.
  • Active DVT, PE or history of these conditions.
  • Active arterial thromboembolic disease (for example, stroke, MI) or a history of these conditions.
  • Known anaphylactic reaction or angioedema to estradiol vaginal cream 0.01%.
  • Known liver dysfunction or disease.
  • Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders.
  • Known or suspected pregnancy

This product is custom-made by expert compounding pharmacists.

These statements have not been evaluated by the Food and Drug Administration (FDA). Please consult your physician before starting any exercise or nutritional supplement program before using this or any products if you are pregnant or have a serious medical condition.

This Product Is FSA/HSA Eligible

Score! You may purchase this product by simply using your FSA/HSA debit card at checkout.

How Do I Use My FSA/HSA Debit Card At MintRx?

  • Place all of your qualifying items in your cart. All MintRx prescriptions, including our custom-made medications, are approved for FSA and HSA purchase. Also, use your FSA/HSA debit for qualified over-the-counter items such as at-home lab tests and acne treatments. We've marked each FSA/HSA eligible item with a badge.
  • Make your purchase using your debit card.

What If I Want To Purchase Items That Are Not FSA/HSA Approved?

If you are also buying non-eligible FSA/HSA items, you are required to make a separate transaction.

What Are FSA and HSA Accounts?

FSA's and HSA's are federal programs that make it easy for you to enjoy significant tax benefits for qualified out-of-pocket medical expenses. Each program works a little differently but with each you avoid federal, state and local income taxes on any funds that you use for qualified medical expenses.

FSA tax benefits are administered by your job. Funds in an amount that you decide —within the program limits—are withdrawn from your paycheck without any payroll tax deductions.

Tax benefits with an HSA may be administered that way but there are also other options.

How Do I Use My FSA/HSA Funds?

You can use a pre-loaded debit card or get reimbursed from your FSA or HSA account after you make your purchase or a combination of both methods.

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