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Compounded Bi-Est Topical Cream


This custom made hormone replacement cream contains two bio-identical forms of women's sex hormones, estradiol and estriol. It is prescribed to treat symptoms of hormonal imbalance and menopause such as hot flashes, vaginal dryness, and low libido. Hormonal imbalance can also cause adult acne and thinning of the skin. Topical application of this HRT cream enables targeted treatment and may improve skin appearance and reduce acne outbreaks.  

You must have a prescription from your physician to purchase this product  

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ERT Options that Fit your Budget & Unique Medical History

Studies and clinical trials show HRT with estrogen can provide much needed relief and health benefits for postmenopausal women. This has empowered more women to step forward and take control of their health.  

However, high costs and limited choices remain an obstacle in HRT. This is where custom-compounded HRT and Estrogen Replacement Therapy (ERT) medications from MintRx is creating new solutions for post-menopausal women. Retail prices for vaginal and topical estrogens are typically hundreds of dollars and may not be covered insurance. Additionally, commercial prescription estrogen formulas have limited options in dosages and delivery methods.

MintRx ERT and HRT prescriptions are available in custom formulations and cost as low as $55.  

The estrogens used in this formula are bioidentical. They are plant-based and produced from diosgenin, an extract of the wild yam. The diosgenin must undergo a 3-step chemical process done in a lab to produce the estrogen. Studies show that eating the wild yam is not effective for ERT or any HRT.

What is the Difference Between Estradiol & Estriol?

The chief female sex hormones are estradiol, estrone and estriol. They are all estrogens (oestrogens) that are naturally created (endogenously) in the body.

Estradiol is the strongest and the most abundant during puberty and a woman's chief reproductive years. It begins to decline around age 35. Estriol (E3) is the weakest of the 3 estrogens and reaches is highest levels during pregnancy. 

By the time a woman reaches menopause, estradiol production stops. The only estrogen produced by the body post-menopause is estrone.

Benefits of ERT with Estradiol and Estriol

Studies show that hormone treatment with estradiol and estriol are effective in providing relief for menopause symptoms caused by lower estrogen levels in the body.  Since estriol is weaker than estradiol, some women may prefer a combination of the two estrogens to prevent any risks they may face using estradiol alone. The choice should be discussed with a physician.

Studies show that estradiol offers protection in premenopausal women against cardiovascular conditions. The natural reduction of estradiol in postmenopausal women is associated with increased coronary risk. To reduce the risk estrone is being studied for possible protection from cardiac events in postmenopausal women.1

What is the Difference Between Estrogen Pills and Topical Creams?

Topical application is absorbed by the body quickly and bypasses the digestive system enhancing the bioavailability of the estrogen. It is capable of increasing estrogen levels within minutes. Relief may begin 1-2 weeks after continued use. Full benefits may take 3-4 weeks. 

Oral ERT circulates throughout the body and is not as targeted as topical. It may not be ideal for women who want the benefits of ERT but do not want estrogen to reach all of the body's organs.

What is Compounded Medicine?

Compounded medications are made by experts who develop recipes specifically for each patient based on their medical condition and needs. They are prepared in small batches and do not require commercial fillers and preservatives that industrial pharmaceuticals require for a long shelf life.

Another bonus: Custom-compounded medications may cost up to 50% to 75% less than commercial prescriptions.

Mint Pharmacy's expert compounding pharmacists create customized prescriptions from scratch using the same active ingredients found in commercially available prescriptions and obtains medications from FDA-approved sources. 

Why Should I Buy Compounded Medicine from MintRx?

With the benefit of personalized medicine at affordable prices, Mint Pharmacy's solutions provide relief for your mind as well as your body. Private, free shipping with the convenience of auto refills and online medical consultations help you continue your HRT.

MintRx is a US certified pharmacy and is accredited by the Pharmacy Compounding Accreditation Board (PCAB).

This product is custom-made by expert compounding pharmacists. These statements have not been evaluated by the Food and Drug Administration (FDA). Please consult your physician before starting any exercise or nutritional supplement program before using this or any products if you are pregnant or have a serious medical condition.


Antonio de Padua Mansur, Tereza Cristina B. F. Silva, Julio Yoshio Takada, et al., “Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease,” The Scientific World Journal, vol. 2012, Article ID 363595, 6 pages, 2012. 

More Information
Use or Effects Menopause Symptoms, Relieve Pain During Sex, Treat Vaginal Dryness, Hormone Replacement Therapy
Is a Prescription Product Yes
Form Cream
Drug Class/Pharmacology Estrogens
Product Specifics

This product is custom-compounded cream and available in the following strengths per gram: 0.625gm; 1mg; or 2mg. Each formula contains a balance of 80% estriol and 20% estradiol. 

How to use:

Apply estradiol cream to both thighs and calves (lower legs). Apply to skin that is clean, completely dry and not red, irritated, or broken. Do not apply to your breasts. 

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

If you forget a dose of estradiol cream but remember more than 12 hours before you are scheduled to apply your next dose, apply the missed dose right away. If you remember less than 12 hours before you are scheduled to apply your next dose, skip the missed dose and continue your regular dosing schedule the next day.

Do not apply extra estradiol cream to make up for a missed dose.

Tell your doctor if any of these symptoms are severe or do not go away:

  • headache breast pain or tenderness
  • nausea
  • diarrhea
  • constipation
  • gas
  • heartburn
  • weight gain or loss
  • mood changes
  • depression nervousness
  • sleepiness
  • difficulty falling asleep or staying asleep
  • changes in sexual desire
  • back pain
  • runny nose
  • cough flu-like symptoms
  • hair loss
  • unwanted hair growth
  • darkening of the skin on the face
  • difficulty wearing contact lenses
  • irritation or redness of the skin at the application area
  • swelling
  • redness
  • burning
  • irritation, or itching of the vagina vaginal discharge

What are symptoms of menopause and low estrogen?

  • Poor sleep
  • Insomnia
  • Anxiety
  • Weight gain
  • Frequent mood changes
  • Depression
  • Vaginal dryness
  • Pain during sex caused by vaginal dryness
  • Decreased libido
  • Hot flashes

What is estrogen replacement therapy (ERT) used for?

  • Relief of menopause symptoms
  • Treating low libido associated with low estrogen
  • Relieving vaginal dryness and pain during sex
  • Preventing osteoporosis
  • Treating ovarian failure
  • Feminizing hormone therapy
  • Maintaining the health of the vagina
  • Treating hormonal imbalance

What does estrogen do?

Estrogen's primary role in women is to regulate the reproductive system. It's also responsible for female secondary sexual characteristics that differentiate females from males.

What causes low estrogen?

Estrogen naturally decreases in women as she approaches menopause. Before menopause, estrogen ranges from 15 to 350 picograms per milliliter (pg/mL). In post-menopausal women, estrogen falls below 30 pg/mL. Estrogen can also decline in women of any age. Childbirth, stress and illness and age are also among the causes. 

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