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Compounded Estradiol Topical Cream .4%, 30gm


Continuing your estrogen replacement therapy (ERT) is easy when it is affordable and custom-made just for you. This compounded bioidentical estradiol cream is for topical use to supplement the body's levels of estrogen as the body approaches menopause and especially post-menopause. Topical application is absorbed by the body quickly and bypasses the digestive system enhancing the bioavailability of the estrogen.

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Save with Custom-Blended Topical Estrogen Cream for ERT 

Transdermal estradiol cream is an alternative to vaginal application. It is indicated for the treatment of menopause symptoms. It works by replacing estrogen that the body produces in low levels when a woman approaches menopause (during her 40s) and reaches menopause. The average age for menopause in the US is 51.

Women may also have low estrogen due to hormonal imbalances caused by ovary failure or other health conditions. ERT may also be prescribed to raise estrogen levels in those cases as well.

Estradiol is the strongest of the three sex hormones called estrogens made in the body. The other two estrogens are estrone and estriol. Estrogens are responsible for female secondary sex characteristics, as well as the health and function of the female reproductive system.

The estrogens used in this formula are defined as bio-identical. They are plant-based and produced from diosgenin, an extract of the wild yam. The diosgenin must undergo a 3-step chemical process done in a lab to produce the estrogen. Studies show that eating the wild yam is not effective for ERT or any HRT.

What is the Difference Between Topical Estrogen and Vaginal Estrogen Creams? 

Vaginal and topical estrogen creams  bypass the digestive system which helps ensure that more of the active ingredient is available for use by the body. Topical and vaginal application work faster than oral estrogen. Their direct absorption into the body has been shown to have less impact on the body's other organs. 

Vaginal application of estradiol is especially ideal for vaginal dryness, thinning of the vaginal walls and pain during sex frequently associated with menopause and reduced estrogen levels.

Topical estradiol is absorbed  through the skin and impacts systemic levels of estrogen but not to the degree of oral ERT. It is typically available in higher dose formulas than vaginal estrogen cream. Topical estrogen creams are usually applied to the thighs and calves.

Estrogen Oral vs Estrogen Patches

ERT can also be administered orally. Even though oral estrogen passes through the digestive system where it loses some potency, it circulates through the entire body and may have more of a systemic impact than vaginal or topical estrogen replacement.

Another delivery method of ERT is transdermal patches. They are the most direct and potent delivery form other than an injection or oral troche. A troche dissolves beneath the tongue and is absorbed directly into the bloodstream.

Discuss with your options for delivery methods as well as hormones you may use for HRT

What is Compounded Medicine?

Compounded medications are made by experts who develop recipes specifically for each patient based on their medical condition and needs. They are prepared in small batches and do not require commercial fillers and preservatives that industrial pharmaceuticals require for a long shelf life.

Mint Pharmacy's expert compounding pharmacists create customized prescriptions from scratch using the same active ingredients found in commercially available prescriptions and obtains medications from FDA-approved sources. 

Why Should I Buy Compounded Medicine from MintRx?

With the benefit of personalized medicine at affordable prices, MintRx's solutions provide relief for your mind as well as your body. Private, free shipping with convenience of auto refills and online medical consultations help you continue your HRT.

MintRx is a US certified pharmacy and is accredited by the Pharmacy Compounding Accreditation Board (PCAB).

This product is custom-made by expert compounding pharmacists. These statements have not been evaluated by the Food and Drug Administration (FDA). Please consult your physician before starting any exercise or nutritional supplement program before using this or any products if you are pregnant or have a serious medical condition.

More Information
Use or Effects Menopause Symptoms, Hormone Replacement Therapy
Is a Prescription Product Yes
Form Cream
Drug Class/Pharmacology Estrogens
Product Specifics

How to use:

Apply estradiol cream to both thighs and calves (lower legs). Apply to skin that is clean, completely dry and not red, irritated, or broken. Do not apply to your breasts. 

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

If you forget a dose of estradiol cream but remember more than 12 hours before you are scheduled to apply your next dose, apply the missed dose right away. If you remember less than 12 hours before you are scheduled to apply your next dose, skip the missed dose and continue your regular dosing schedule the next day.

Do not apply extra estradiol cream to make up for a missed dose.

Tell your doctor if any of these symptoms are severe or do not go away:

  • headache breast pain or tenderness
  • nausea
  • diarrhea
  • constipation
  • gas
  • heartburn
  • weight gain or loss
  • mood changes
  • depression nervousness
  • sleepiness
  • difficulty falling asleep or staying asleep
  • changes in sexual desire
  • back pain
  • runny nose
  • cough flu-like symptoms
  • hair loss
  • unwanted hair growth
  • darkening of the skin on the face
  • difficulty wearing contact lenses
  • irritation or redness of the skin at the application area
  • swelling
  • redness
  • burning
  • irritation, or itching of the vagina vaginal discharge

What are symptoms of menopause and low estrogen?

  • Poor sleep
  • Insomnia
  • Anxiety
  • Weight gain
  • Frequent mood changes
  • Depression
  • Vaginal dryness
  • Pain during sex caused by vaginal dryness
  • Decreased libido
  • Hot flashes

What is estrogen replacement therapy (ERT) used for?

  • Relief of menopause symptoms
  • Treating low libido associated with low estrogen
  • Relieving vaginal dryness and pain during sex
  • Preventing osteoporosis
  • Treating ovarian failure
  • Feminizing hormone therapy
  • Maintaining the health of the vagina
  • Treating hormonal imbalance

What does estrogen do?

Estrogen's primary role in women is to regulate the reproductive system. It's also responsible for female secondary sexual characteristics that differentiate females from males.

What causes low estrogen?

Estrogen naturally decreases in women as she approaches menopause. Before menopause, estrogen ranges from 15 to 350 picograms per milliliter (pg/mL). In post-menopausal women, estrogen falls below 30 pg/mL. Estrogen can also decline in women of any age. Childbirth, stress and illness and age are also among the causes. 

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