Estradiol Topical Cream

In stock
SKU
ESTA-0004-10-MRX-01
Special Price $37.50 Regular Price $50.00

How it works

Step 1. No Prescription?

No problem! Choose "I need a prescription" and get treated online by one of our participating providers in 5 minutes. Avoid the hassle and expense of visiting a doctor's office. (not available in LA, RI, VT)

Step 2. You Have a Prescription

Just upload a photo of your prescription after checkout. You can also text us a picture of your prescription or prescription label to 561-619-5169. Only choose "I have a prescription" if you have an actual prescription from your doctor for this specific drug.

Step 3. Your Order Is Processed

Once we receive your prescription from our doctor or yours, we will process your order. We only authorize your credit card at checkout and won't charge your card until we obtain a valid prescription.

Step 4. Your Medication Is Shipped

Your medication is on its way! We ship directly to your door. Never wait in a pharmacy line again!


Continuing your Estrogen Replacement Therapy (ERT) is easy when it is affordable and custom-made just for you. This compounded bioidentical estradiol cream is for topical use to supplement the body's levels of estrogen as the body approaches menopause and especially post-menopause. Topical application is absorbed by the body quickly and bypasses the digestive system enhancing the bioavailability of the estrogen. .4% estradiol delivered in a 30gm pump.

Save With Custom-Blended Topical Estrogen Cream For HRT

Transdermal estradiol cream is an alternative to vaginal application. It is indicated for the treatment of menopause symptoms. It works by replacing estrogen that the body produces in low levels when a woman approaches menopause (during her 40s) and reaches menopause. The average age for menopause in the US is 51.

Women may also have low estrogen due to hormonal imbalances caused by ovary failure or other health conditions. Hormone Replacement Therapy (HRT) with estrogen may also be prescribed to raise estrogen levels in those cases as well.

Estradiol is the strongest of the three sex hormones called estrogens made in the body. The other two estrogens are estrone and estriol. Estrogens are responsible for female secondary sex characteristics, as well as the health and function of the female reproductive system.

The estrogens used in this formula are defined as bioidentical. They are plant-based and produced from diosgenin, an extract of the wild yam. The diosgenin must undergo a 3-step chemical process done in a lab to produce the estrogen. Studies show that eating the wild yam is not effective for ERT or any HRT.

Topical Estrogen vs Vaginal Estrogen Cream

Vaginal and topical estrogen creams bypass the digestive system which helps ensure that more of the active ingredient is available for use by the body. Topical and vaginal application work faster than oral estrogen. Their direct absorption into the body has been shown to have less impact on the body's other organs.

Vaginal application of estradiol is especially ideal for vaginal dryness, thinning of the vaginal walls and pain during sex frequently associated with menopause and reduced estrogen levels.

Topical estradiol is absorbed through the skin and impacts systemic levels of estrogen but not to the degree of oral estrogen. It is typically available in higher dose formulas than vaginal estrogen cream. Topical estrogen creams are usually applied to the thighs and calves.

Estrogen Oral vs Estrogen Patches

ERT can also be administered orally. Even though oral estrogen passes through the digestive system where it loses some potency, it circulates through the entire body and may have more of a systemic impact than vaginal or topical estrogen replacement.

Another delivery method of ERT is transdermal patches. They are the most direct and potent delivery form other than an injection or oral troche. A troche dissolves beneath the tongue and is absorbed directly into the bloodstream.

Discuss with your options for delivery methods as well as hormones you may use for HRT.

This product is made by a MintRx partner, a 3rd party licensed, sterile compounding pharmacy.

These statements have not been evaluated by the Food and Drug Administration (FDA). Please consult your physician before starting any exercise or nutritional supplement program before using this or any products if you are pregnant or have a serious medical condition.

What is Compounded Medicine?

Compounded medications are made by experts who develop recipes specifically for each patient based on their medical condition and needs. They are prepared in small batches and do not require commercial fillers and preservatives that industrial pharmaceuticals require for a long shelf life. Custom-compounded medications may cost up to 50% to 75% less than commercial prescriptions.

MintRx's expert compounding pharmacists create customized prescriptions from scratch using the same active ingredients found in commercially available prescriptions and obtains medications from FDA-approved sources.

Why Buy Compounded Medicine from MintRx?

With the benefit of personalized medicine at affordable prices, MintRx's solutions provide relief for your mind as well as your body. Private, free shipping with the convenience of auto refills and online medical consultations help you continue your HRT.

These statements have not been evaluated by the Food and Drug Administration (FDA). Please consult your physician before starting any exercise or nutritional supplement program before using this or any products if you are pregnant or have a serious medical condition.

This compounded product contains a total of 30g of custom blended .4% bioidentical estradiol. It is delivered in a pump with auto measuring. The potency is 4mg per gram.

How to Use

Apply estradiol cream to both thighs and calves (lower legs). Apply to skin that is clean, completely dry and not red, irritated, or broken. Do not apply to your breasts.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

If you forget a dose of estradiol cream but remember more than 12 hours before you are scheduled to apply your next dose, apply the missed dose right away. If you remember less than 12 hours before you are scheduled to apply your next dose, skip the missed dose and continue your regular dosing schedule the next day.

Do not apply extra estradiol cream to make up for a missed dose.

Tell your doctor if any of these symptoms are severe or do not go away:

  • Headache breast pain or tenderness
  • Nausea
  • Diarrhea
  • Constipation
  • Gas
  • Heartburn
  • Weight gain or loss
  • Mood changes
  • Depression or nervousness
  • Sleepiness
  • Difficulty falling asleep or staying asleep
  • Changes in sexual desire
  • Back pain
  • Runny nose
  • Cough or flu-like symptoms
  • Hair loss
  • Unwanted hair growth
  • Darkening of the skin on the face
  • Difficulty wearing contact lenses
  • Irritation or redness of the skin at the application area
  • Swelling
  • Redness
  • Burning
  • Irritation, or itching of the vagina vaginal discharge

These products are made by a MintRx partner, a 3rd party licensed, sterile compounding pharmacy.

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