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Generic Estrace .01% Vaginal Cream, 42.5gm


With the availability of generic Estrace, women experiencing symptoms of decreased estrogen have access to affordable treatment. Estradiol (as estradiol hemihydrate) is the active ingredient in brand names Estrace, Vagifem, Yuvafem. Brand name Estrace retails at $300 plus. Save close to 75% when you buy generic Estrace at Mint Pharmacy. .01% 42.5 gm tube with applicator.

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Relief For Vaginal Dryness

Low dose .01% estradiol vaginal cream is prescribed as a topical option to treat menopausal symptoms, vaginal dryness, low libido, pain during sex and imbalanced vaginal pH associated with vaginal infections. 

Advantages of topical estrogen over prescription oral estrogen include quicker absorption and targeted therapy. Targeted topical therapy avoids the gastrointestinal tract and can limit circulation throughout the body. This reduces the chance of interactions with other medications and impact to other parts of the body. 

HRT medical guidelines for women with an intact uterus include estrogen plus progestin. Women who have had a hysterectomy may be prescribed estrogen alone. Only a doctor can prescribe these medications. Discuss your options with your physician. Women with a history of certain cancers may not be advised to undergo HRT with estrogen, progesterone or other sex hormones.

What does estrogen do?

Estrogen's primary role in women is to regulate the reproductive system. It's also responsible for female secondary sexual characteristics that differentiate females from males.

What causes low estrogen?

Estrogen naturally decreases in women as she approaches menopause. Before menopause, estrogen ranges from 15 to 350 picograms per milliliter (pg/mL). In post-menopausal women, estrogen falls below 30 pg/mL. Estrogen can also decline in women of any age. Childbirth, stress and illness and age are among the causes. 

Symptoms of low estrogen include hot flashes, moodiness, and night sweats. Lesser known but often just as common symptoms include vaginal dryness, low libido, weakening of bones and thinning of the skin. Estrogen is prescribed to counteract and prevent these conditions.

The natural decline of estrogen in women coincides with three major stages of the reproductive cycle: perimenopause, menopause, and postmenopause. The perimenopause stage is the 10 years leading up to menopause. Menopause is defined as the stage when a woman does not have her period for 12 consecutive months. Postmenopause is the years following.

What are the benefits of taking estrogen?

  • Osteoporosis prevention
  • Treat ovarian failure
  • Specific cancer treatment
  • Feminizing hormone therapy
  • Maintain the health of the vagina
  • Treat hormonal imbalance
  • Treat menopause symptoms
  • Treat low libido associated with low estrogen

Topical estradiol (generic Estrace) is quickly absorbed into the body and capable of increasing estrogen levels within minutes, reaching the peak delivery in half an hour.1 Relief from estradiol may begin 1-2 weeks after continued use. Full benefits may take 3-4 weeks. 


1Krause M, Wheeler TL 2nd, Richter HE, Snyder TE. Systemic effects of vaginally administered estrogen therapy: a review. Female Pelvic Med Reconstr Surg. 2010;16(3):188–195. doi:10.1097/SPV.0b013e3181d7e86e

To ensure that we provide you with the best price, we may substitute one generic for another. 

More Information
Use or Effects Menopause Symptoms, Relieve Pain During Sex, Treat Vaginal Dryness, Hormone Replacement Therapy
Is a Prescription Product Yes
Form Cream
Drug Class/Pharmacology Estrogens
Product Specifics

Estradiol vaginal cream 0.01% is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.

Estradiol vaginal cream 0.01% should not be used in women with any of the following conditions:

  • Undiagnosed abnormal genital bleeding.
  • Known, suspected, or history of cancer of the breast. 
  • Known or suspected estrogen-dependent neoplasia. 
  • Active DVT, PE or history of these conditions.
  • Active arterial thromboembolic disease (for example, stroke, MI) or a history of these conditions. 
  • Known anaphylactic reaction or angioedema to estradiol vaginal cream 0.01%. 
  • Known liver dysfunction or disease. 
  • Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders.
  • Known or suspected pregnancy
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