Gonal-F is a hormone prescribed to treat female infertility by stimulating the ovaries to release multiple follicles and promoting egg maturation. It treats male infertility by increasing sperm count. Gonal F belongs to the drug class called gonadotropins. It is produced in the anterior pituitary. Its mode of action is to act on the ovaries and gonads to produce sex hormones. It is a naturally-occurring hormone essential to human reproduction.
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You should not use Gonal-F if you are allergic to it, or if you have:
- An untreated or uncontrolled disorder of the thyroid, pituitary gland, or adrenal glands
- Heavy or abnormal vaginal bleeding that has not been checked by a doctor
- An ovarian cyst
- Cancer of the breast, ovary, uterus, testicle, hypothalamus, or pituitary gland
- If you are allergic to benzyl alcohol, follitropin, sucrose, neomycin, sodium phosphate or streptomycin.
- Do not use Gonal-F if you are already pregnant. You may need to have a negative pregnancy test before starting this treatment. Tell your doctor right away if you become pregnant.
Tell your doctor if you have ever had:
- Unusual vaginal bleeding
- Polycystic ovary disease
- Twisting (torsion) of your ovary
- Stroke or blood clot
- Stomach surgery
Fertility treatment may increase your chance of having multiple births (twins, triplets, etc). These are high-risk pregnancies both for the mother and the babies. Talk to your doctor if you have concerns about this risk.
You should not breastfeed while using Gonal-F.
You must remain under the care of a doctor while using Gonal-F.
Gonal-F is injected under the skin. A healthcare provider may teach you how to properly use the medication by yourself.
Follow your doctor's instructions very carefully.
Gonal-F side effects:
Get emergency medical help if you have signs of an allergic reaction:
- Difficult breathing
- Swelling of your face, lips, tongue, or throat
Some women using Gonal-F develop ovarian hyperstimulation syndrome (OHSS), a potentially life-threatening condition.
Stop using this medicine and call your doctor right away if you have symptoms of OHSS during or shortly after using Gonal-F:
- Severe pain in your lower stomach, nausea, vomiting, diarrhea; bloating, rapid weight gain; little or no urination; or trouble breathing.
Also call your doctor at once if you have:
- Severe pelvic pain on one side
- Cough with bloody mucus ever
- Sore throat, swollen glands
- A lump or swelling in your testicles signs of acute respiratory distress syndrome--fever with shortness of breath or rapid breathing
- Signs of a blood clot--sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg.
Common side effects may include:
- Redness, swelling, or bruising where an injection was given
- An ovarian cyst
- Breast pain or swelling
- Stuffy nose, sneezing, sinus pain
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.