Generic Clomid (Clomiphene Citrate), 50mg
Clomiphene citrate, marketed under the brand names Clomid and Serophene, is a non-steroidal medicine with FDA-approval to treat female infertility. It is also prescribed off-label to treat male infertility and increase male testosterone levels. Minimum order is 5 tablets.
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The use of Clomid, clomiphene citrate, in women is a first-line treatment for female infertility caused by defective ovarian function. It is one of the least costly fertility treatments. Your gynecologist can prescribe clomiphene citrate eliminating the additional cost of seeing a fertility specialist. It's also easier to administer, less invasive and less expensive than in-vitro fertilization.
Clomiphene citrate has been used around the world for more than 50 years and is considered one of the most essential drugs in the world by the World Health Organization (WHO). Clomiphene is not prescribed for women whose infertility is caused by conditions other than ovarian malfunction. These conditions may include endometriosis, blocked fallopian tubes, and certain cancers.
How does clomiphene work in women?
Clomiphene corrects insufficient ovarian behavior by stimulating ovulation. Successful ovulation with clomiphene citrate can be as high as 73%.1 Defective ovarian function is defined as:
- Absence of ovulation
- Irregular ovulation
- Lack of quality eggs
How quickly does clomiphene work?
In best cases, a woman can expect to ovulate within 5 to 10 days after taking her last dose of clomiphene in her 5-day course of treatment.
What are the chances of getting pregnant on clomiphene?
An analysis2 of published results on the effectiveness of clomiphene reported:
- 73% of women eventually ovulated
- 36% achieved pregnancy
- 29% gave birth
How does clomiphene cause ovulation?
Clomiphene sets off a series of events that increase the chances of pregnancy. First, it blocks estrogen receptors in the hypothalamus. When the hypothalamus (erroneously) detects low estrogen, it directs the pituitary gland to increase follicle stimulating hormone (FSH) and luteinizing hormone (LH) production. FSH and LH then raise production of the essential reproductive hormones estrogen and progesterone.
What is the role of FSH and LH in women?
Oocytes (immature eggs) reside inside of ovaries enclosed within follicles. Midway through a woman's menstrual cycle, FSH and LH naturally surge to set off the process of egg growth and the eventual release of a mature egg by the ovaries. If an egg is fertilized, LH supports the growth of the corpus luteum, a mass of cells that form around a fertilized egg.
Will I conceive twins on clomiphene?
Theoretically, clomiphene can result in multiples by causing the release and growth of more than one egg, but in-vitro fertilization is more closely linked to multiples.3 During a normal menstrual cycle, only one follicle produces a mature egg. Artificial ovarian stimulation with clomiphene citrate can cause the growth of more than one follicle, thus resulting in more than one egg suitable for fertilization.
Does clomiphene increase estrogen in women?
Yes, clomiphene may increase estrogen in women by impacting several hormones which trigger estrogen production in women.
How long do I take clomiphene?
Your physician will advise you on how to take clomiphene. In general, one course of clomiphene treatment in women is the daily intake for 5 days. In most cases, women are not advised to complete more than 3 clomiphene treatment cycles.
Can clomiphene treat male infertility?
Yes, clomiphene citrate may be prescribed off-label to treat male infertility. Clomid for men can be effective in increasing sperm count and raising overall testosterone levels.
How does clomiphene treat male infertility?
In men, generic Clomid stimulates the synthesis and release of FSH by the pituitary gland. FSH signals the Sertoli cells to produce sperm. Clomiphene citrate also increases LH in men. LH fuels the synthesis of Leydig cells, which produce testosterone.
1,2 Roy Homburg, Clomiphene citrate—end of an era? a mini-review, Human Reproduction, Volume 20, Issue 8, August 2005, Pages 2043–2051, https://doi.org/10.1093/humrep/dei042
3 Kulkarni A, Jamieson D, Jones H et al. Fertility Treatments and Multiple Births in the United States. New England Journal of Medicine. 2013;369(23):2218-2225. Doi: 10.1056/NEJMoa1301467
To ensure that we provide you with the best price, we may substitute one generic for another.
|Use or Effects||Female Fertility Treatment|
|Is a Prescription Product||Yes|
|Drug Class/Pharmacology||Ovulatory Stimulants|
Clomiphene citrate is a non-steroidal fertility medicine that is FDA-approved to treat female infertility. It may also be prescribed off-label to treat male infertility. Brand names for clomiphene citrate are Clomid and Serophene.
Possible side effects of clomiphene citrate include:
See package insert for full prescribing information and warnings.
What does clomiphene citrate do?
Clomiphene is FDA-approved to treat infertility in women. It works by stimulating an increase in the hormones that support the egg growth and the release of ovulation, the release of mature eggs. Clomid and Serophene are brand names for clomiphene citrate.
Can Clomid be used to treat male infertility?
Yes, clomiphene citrate/Clomid may be prescribed off-label for male infertility. In some men, Clomid can successfully treat infertility by increasing testosterone levels and sperm count. Low sperm count is one of the main reasons men experience infertility.
What are the chances of getting pregnant on Clomid?
An article in the journal Human Reproduction summarized multiple studies on clomiphene citrate use among 5,000 women. According to the report:
- 73 percent of women ovulated on clomiphene citrate
- 36 percent of women achieved pregnancy
- 29 percent of women gave birth
Does Clomid increase testosterone levels?
Yes, if Clomid works successfully, it will block estrogen's interaction with the pituitary gland, causing an increase in LH, FSH, and testosterone in the body. However, too much Clomid can cause decreased levels of testosterone.
How is Clomid taken?
General recommendations for taking Clomid are to begin with the lowest dose of one 50 mg tablet daily for 5 days. At the physician's discretion, Clomid intake may be increased if the initial treatment of 50 mg does not successfully stimulate ovulation.
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