Doctors are increasingly prescribing sermorelin to improve quality of life, promote healing, preserve and restore cognitive function and as part of an overall active aging program. Sermorelin increases the body's release of natural human growth hormone (HGH). It is a polypeptide and classified as a growth hormone secretagogue. HGH is a protein responsible for growth and renewal throughout the body. 15mg in a 10ml injectable solution.
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Learn About The Benefits Of Sermorelin To Boost Natural HGH Levels
Sermorelin Reported Benefits
Studies have shown stimulating HGH secretion with sermorelin may produce the following benefits:
- Revitalize sex drive and performance
- Restore skin elasticity, thickness and texture
- Increase lean muscle mass
- Decrease body fat
- Protect and restore cognitive health
- Improve sleep quality
What Is Sermorelin?
Sermorelin, also known as GRF 1‐29 or Geref, is a peptide hormone and analog of naturally-occurring growth hormone-releasing hormone (GHRH). A drug analog is a substance that is similar to another compound. Sermorelin consists of the first 29 amino acid sequence in internally-made growth hormone.
How Does Semorelin WorK?
Sermorelin binds to the GHRH receptor and mimics its effects, which is to stimulate the pituitary gland to release natural growth hormone.
Growth hormone peaks in puberty and naturally begins declining in our 30s. But low growth hormone is not just linked to age. Some adults and children are born with or develop medical conditions that cause growth hormone deficiency.
Sermorelin may be prescribed to treat growth hormone deficiency or as part of an overall adult active aging program.
What Does Growth Hormone Do?
Growth hormone is made naturally in the anterior of the pituitary gland. It assists in the development of muscle, tissue, the somatic nervous system and helps regulate metabolism.
Growth hormone secretions begins to wane after age 30. Additionally, studies show obesity,1 lack of exercise and a poor diet can inhibit growth hormone secretion.
Lower growth hormone levels are associated with aging (decreased muscle mass, cognitive decline), increased body fat and diminished sleep quality.2
Sermorelin may help overcome those barriers and help forge a path to better health and active aging.
Is Sermorelin The Same As HGH?
No, sermorelin is not the same as natural (endogenous) HGH. It also should not be confused with recombinant Human Growth Hormone (rhGH).
rhGH is a lab-synthesized replica of HGH. rhGH is FDA-approved to treat growth hormone deficiency in adults and children and wasting from certain diseases such as HIV.
rhGH works by adding growth hormone to the body rather than stimulating its release. rhGH use is illegal in the US for any other purpose than its FDA-approved indications.
Growth hormone secretagogues like sermorelin may be legally prescribed for active aging and other potential benefits of increased growth hormone.
What Are Peptides?
Peptides are short chains of amino acids as opposed to proteins which are long chains of amino acids. Proteins are multiple peptides held together by peptide bonds. The unique amino acid sequences in each peptide defines its function. Different arrangements of peptides define each protein's role.
What Is the Difference Between GH And IGF-1?
Growth hormone and IGF-1 are both growth hormones that work interdependently. The pituitary gland secretes GH, then growth hormone triggers the synthesis of IGF-1, mainly (about 80%) in the liver but also in bone (about 20%).
IGF-1 modulates the effects of growth hormone and plays a key role in chondrogenesis (bone development).
GH has anti-insulin-like effects while IGF-1 has insulin-like effects. When IGF-1 and HG levels are balanced they help maintain homeostasis of blood sugar levels.
1 Salvatori, R. Growth hormone deficiency in patients with obesity. Endocrine 49, 304–306 (2015). https://doi.org/10.1007/s12020-015-0571-4
2 Garcia JM, Merriam GR, Kargi AY. Growth Hormone in Aging. [Updated 2019 Oct 7]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279163/
These statements have not been evaluated by the Food and Drug Administration (FDA). This drug is not meant to diagnose‚ treat or cure any disease or medical condition. Please consult your doctor before starting any exercise, nutritional supplement program, using this drug, and/or any prescription or OTC product during pregnancy or if you have a serious medical condition.
This product is made by a MintRx partner, a 3rd party licensed, sterile compounding pharmacy.
Sermorelin Acetate for Injection (GHRH)
Sermorelin Acetate is compounded in the following strength: 15mg (15,000 micrograms per vial).
WARNING: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
How to administer this medication unless directed otherwise by your doctor or pharmacist:
Step 1: Mix the bacteriostatic water provided into the vial of sermorelin using a large “mixing syringe” with attached needle. This is done by using the mixing syringe to draw the appropriate amount of bacteriostatic water and dispensing it into the vial of Sermorelin. Usually the mixing syringe is between 3ml and 10ml in size (not to be confused with the much smaller syringes used to inject).
For 15mg vial of sermorelin using the mixing syringe, dilute (mix) 10ml of bacteriostatic water.
Step 2: Next, swirl the vial with a gentle rotary motion until contents are dissolved - DO NOT SHAKE.
Step 3: Now you are ready to administer your sermorelin.
Please note that 10 units on the syringe = 150mcg of sermorelin when measured on the syringe used to inject, usually an “insulin” syringe. So, if your prescribed dose is 750mcg this means you draw to the 50 unit mark on the syringe.
You may use this mixture for up to 90 days, but remember to keep it refrigerated after mixing. If accidentally left out of the fridge, don’t worry, Sermorelin can be left at room temperature for 72 hours after being mixed. *Be sure to properly dispose of all syringes and needles after use.
Measuring your dose on the syringe:
100mcg (1mg) = 50 units on the insulin syringe
500mcg (0.5mg) = 25 units on the insulin syringe
mcg = microgram (measurement of the amount of medication)
mL = milliliter (measurement of the amount of medication)
1ml = 1cc
Important Information About Sermorelin:
Individual pharmacies may offer different strengths. Always be sure to check the label to confirm that you have received the correct strength. The diluent is Bacteriostatic Water for Injection, USP containing 0.9% Benzyl Alcohol is added as an antimicrobial preservative.
Do not use any other diluent unless approved by the prescribing physician. Refrigerate after reconstitution.
Before using this medicine, inform your Doctor or Pharmacist if:
- You are allergic to any prescription or non-prescription medicine
- Taking other medicines or have other medical problems
- Pregnant, planning a pregnancy or breastfeeding
Check with your Doctor, Pharmacists, or Nurse if information in this leaflet causes you concern or if you want additional information about your medicine.
Common uses for this medicine:
- For replacement of endogenous growth hormone in adults with growth hormone deficiency who meet either of the following two criteria:
- Adult Onset: Patients who have growth hormone deficiency either alone, or associated with multiple hormone deficiencies (hypopituitarism), as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or trauma.
- Childhood Onset: Patients who were growth hormone deficient during childhood who have growth hormone deficiency confirmed as an adult before replacement therapy is started.
Use this medicine exactly as directed on the label, unless instructed differently by your doctor.
*DO NOT inject if the solution is cloudy or contains particles. Contact your doctor or pharmacy.
What to do if you miss a dose: Take when remembered unless time for the next dose. No double doses.
The following adverse reactions, in decreasing order of frequency, have been reported following sermorelin administration:
- Transient warmth and/or flushing of the face
- Injection site pain
- Redness and/or swelling at injection site
- Nausea or vomiting
- Strange taste in mouth
- Tightness in the chest
Approximately one in four patients given repeated doses of one or more of the three forms of GRH (1-29, 1-40, and 1-44) has developed antibodies to GRH.
The clinical significance of these antibodies is unknown. One patient who developed antibodies to GRH (1-44) also experienced an allergic reaction described as severe redness, swelling, and urticaria at the injection sites. No long-lasting effects from this reaction were reported. No symptomatic allergic reactions to GRH (1-29) have been reported.
Under certain circumstances a prescription drug's effectiveness may be affected by exposure to extremes of heat, cold, or humidity.
How to store this medicine: Refrigerate in original container away from children. Do not freeze. Discard unneeded medicine.
Where should I store my medicine? Store at controlled room temperature, 20°C-25°C. Excursions permitted between 15°C and 30°C. Brief exposure to temperatures up to 40°C may be tolerated. However, such exposure should be minimized.
The product is to be transferred to proper storage conditions without delay, as instructed by the package insert, ideally within two hours of receipt.
If you have any questions, call your MintRx Pharmacist at 866-855-6468.
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