Compounded Thymosin Alpha 1
Thymosin alpha 1 is a natural peptide produced in the thymus to modulate the immune system.
Supplied in a 5ml vial containing 3,000 mcg/mL (3mg/mL) concentration of thymosin alpha 1.
Prescription Product: We will ask for your prescription information after checkout.
How Is Thymosin Alpha1 Supplied:?
You will receive a 5mL vial/15mg at 3,000 mcg/mL (3mg/mL) concentration of compounded, synthesized Thymosin Alpha1 and injection syringes.
How Do I Use Thymosin Alpha1?
Your physician or pharmacist will provide exact dosing instructions for you but dosing recommendations are: Inject 0.15 units daily or Inject 0.10 units daily.
Overview: Thymosin alpha 1 is a peptide containing 28 amino acid residues that are N-terminally acetylated and proteolytically processed from prothymosin alpha. Thymosin alpha 1 was isolated by Goldstein and coworkers from thymosin fraction 5, a mixture of peptides from calf thymus in the 1970s. It is used to improve immune responses in times of need.
Ta1 is pleiotropic— improves innate immunity when needed, downregulates immunity when not needed. Ta1 is a thymic peptide that demonstrates a profound ability to restore immune system homeostasis in different physiological and pathological conditions (e.g viral infections, cancer, immunodeficiency, vaccination support and immunosenescence) acting as multitasking protein depending on the host state of inflammation or immune dysfunction.
Thymosin alpha 1 helps the body induce effective host-derived immune effectors and balance the Th1/Th2 arms of immunity. These effector cells improve various immunomodulatory properties that lead to augmentation of T lymphocyte function, including modulation of interleukin-2 (IL-2), stimulation of interferon-g (IFN-g) production, induction of T lymphocyte and natural killer (NK) cells and stimulation of thymopoiesis. Ta1 has also been reported to upregulate MHC Class I expression in antigen-presenting cells. Additionally, Ta1 downregulates the activity of terminal deoxynucleotide transferase (TdT) in TdT1 thymocytes, suggesting a role for Ta1 in thymocyte maturation. Ta1 has also been found to antagonize both activation induced (anti-CD3) and glucocorticoid-induced thymocyte apotheosis. It has also been reported that Ta1 stimulates activity of Indoleamine-2,3-Dioxygenase (IDO), leading to an increase in FoxP3 IL-10 producing regulatory T cells. This increase leads to feedback inhibition of cytosine production, hence dampening immune response to prevent a pro-inflammatory cytokine storm and possibly autoimmune phenomena.
Thymosin alpha 1 has been used to support immunity in over 3,000 patients and in over 70 clinical studies, either as monotherapy or in conjunction with current allopathic medicines. The lack of significant side effects with thymosin alpha 1 is in sharp contrast to other major immune response modulators such as IFN and IL-2, which can lead to flu-like symptoms including malaise, fever, headache, chills and pulmonary edema (with IL-2).
Potential side effects and/or contraindications:
- Thymosin alpha 1 peptide given subcutaneously is reported safe and efficacious in recommended dosages.
- Since 1979, thymosin alpha-1 is well tolerated. Ta1 has demonstrated a very favorable toxicity profile in more than 3,000 individuals treated to date, including patients with hepatocellular carcinoma, non-small-cell lung cancer, melanoma, and hepatitis B and C.
- Thymosin alpha 1 has been reported to be well tolerated even in patients with decompensated liver disease, renal disease requiring hemodialysis and primary immunodeficient individuals.
- As with all injections, redness and pain at the site of injection may be present.
- Rare adverse reactions include erythema, transient muscle atrophy, polyarthralgia combined with hand edema, and rash.
- A transient increase in ALT to more than twice baseline value can occur during thymosin alpha 1 therapy. When ALT flare occurs, thymosin alpha 1 should generally be continued unless signs and symptoms of liver failure are observed.
- Use caution if administering to pregnant or nursing women.
- Do not use in individuals being deliberately immunosuppressed.
Under certain circumstances a prescription drug's effectiveness may be affected by exposure to extremes of heat, cold, or humidity. Where should I store my medicine? Store at controlled room temperature. Store at 20°C to 25°C. Excursions permitted between 15°C and 30°C. Brief exposure to temperatures up to 40°C may be tolerated however, such exposure should be minimized. The product is to be transferred to proper storage conditions without delay, as instructed by the package insert, ideally within two hours of receipt.
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